Palmer, ScD, professor of epidemiology at Boston University. BMI is a measure of body fat.
Messenger White women in the U. There has been a 35 percent decrease in breast cancer mortality rate from The breakdown by race over this period, however, shows a different story. Death rates for black women decreased by 23 percent, while the death rates for white women declined by 42 percent.
A big, but not the only, reason for this is that white women tend to more frequently get two subtypes of breast cancers, called ER-positive or HER2-positivefor which we now have very effective targeted treatments.
Black women, however, are two to three times more likely than white women to get an aggressive type of breast cancer called triple negative breast cancer, for which there are still no approved targeted treatments. Researchers do not yet know all the reasons why this is so, but are looking for answers.
Research has vastly improved breast cancer treatments and survival rates over the years, with a five-year survival rate for localized breast cancer at We study breast cancer, with a special emphasis on health disparities.
Here are some of the trends we see. Disturbing numbers First, some statistics that lay out the extent of the problem. About 1 in 8 American non-Hispanic white women, and about 1 in 9 African-American women will suffer from breast cancer in their lives. While breast cancer is slightly less prevalent in African-American women, it is much more likely to be diagnosed at a later stage in them.
About 37 percent of white patients and about 47 percent of black patients will have cancers that have spread from their breast to nearby lymph nodes at diagnosis.
When the disease has spread, it typically presents a greater treatment challenge. In fact, the five-year survival rate for breast cancer patients with distant metastasis, or disease that has traveled to another organ such as the liver or bone, is In addition, the aggressive triple negative type of breast cancer accounts for percent of tumors in white womenbut about percent in black women.
Triple negative breast cancer is particularly hard to treat because it does not respond to targeted treatments that have proven to be effective in treating breast cancers that test positive for certain receptors on cancer cell surfaces. Internal environment Beyond triple negative cancer itself, there also seem to be racial differences in what we call the tumor microenvironment of the cancer cells.
Tumor microenvironment is the immediate cellular environment of the cancer cells, including surrounding blood vessels, immune cells, signaling molecules and the tissue matrix that surrounds tumor cells i.
Since the tumor microenvironment can affect behavior of the tumor cells and their response to treatments, these racial differences could impact tumor biology and disease progression.
Studies have also uncovered racial differences in gene expression patterns of cancer cells, in which genes are over-expressed or under-expressed in the tumor cells of black versus white women. A triple negative breast cancer cell, showing the heterogeneity of its cells. Heterogeneity of breast cancer also poses challenges for treatment.
As a result, cancer cells may harbor higher-than-normal or lower-than-normal copies of genes compared to healthy cells.African-American women have highest obesity rate: CDC says.
A A. WASHINGTON (AP) - Nicole Ari Parker was motivated by frustration. For Star Jones, it was a matter of life or death. Toni Carey. Obesity and Coronary Artery Disease. Obesity is an independent risk factor for the development of coronary artery disease (CAD) in women and is an important modifiable risk factor for prevention of CAD.
11 The mechanism of action is likely the relationship between obesity and insulin resistance. In a large cohort study of 37, women in Washington state, women . No population in the United States has a higher obesity rate than African American women, four out of five of whom are overweight or obese, according to a study by the Centers for Disease Control and Prevention.
In the general adult population, 70 percent of adults are overweight or obese.
New Cases. Breast cancer is the most commonly diagnosed cancer among black women, and an estimated 30, new cases are expected to be diagnosed in African-American women at risk. With the obesity epidemic disproportionally affecting black women, APA and the Association of Black Psychologists co-hosted a summit to explore the intersection of race, stress and social context — as well as the culturally sensitive interventions that can make a difference.
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